鍗楁搗鎵�鐮旂┒鎻ず鐜姹炴毚闇插涓崕椴庡辜浣撶殑姣掓�ф満鍒?/h3>
榪戞棩錛屼腑鍥芥按浜х瀛︾爺絀墮櫌鍗楁搗姘翠駭鐮旂┒鎵�涓崕椴庝繚鎶ょ爺絀跺洟闃熷湪鐜閲嶉噾灞炴睘姹℃煋鐗╁涓崕椴庡辜浣撶殑姣掓�ф満鍒剁爺絀跺彇寰楁柊榪涘睍錛屼負(fù)寮�灞曟繏鍗辯墿縐嶄腑鍗庨矌鐨勬搗媧嬬幆澧冮闄╄瘎浼版彁渚涗簡(jiǎn)縐戝渚濇嵁銆傜浉鍏崇爺絀舵垚鏋滀互鈥?span style="font-family: "times new roman";">Integrated transcriptomics and metabolomics reveal the toxic mechanisms of mercury exposure to an endangered species Tachypleus tridentatus鈥濅負(fù)棰樺彂琛ㄤ簬Environmental Toxicology and Pharmacology鏈熷垔錛圛F 4.3錛変笂錛堣阿鏈ㄥ▏鍜岄矋铏炲洯涓哄叡鍚岀涓�浣滆�咃紝棰夋檽鍕囧崥澹負(fù)閫氳浣滆�咃級(jí)銆?/p>
姹炴槸涓�縐嶄互澶氱褰㈠紡銆佸箍娉涜�屾寔涔呭湴姹℃煋姘翠綋鐨勯噸閲戝睘錛屽叿鏈夐珮姣掓�с�侀潪鐢熺墿闄嶈В鎬у拰鐢熺墿瀵岄泦鎬э紝琚仈鍚堝浗鐜瑙勫垝緗插垪涓哄鍏ㄧ悆鑼冨洿浜х敓褰卞搷鐨勫寲瀛︾墿璐紝宸叉垚涓哄叏鐞冨箍娉涘叧娉ㄧ殑鐜姹℃煋鐗╀箣涓�銆?/p>
鍗楁搗鎵�鍥㈤槦搴旂敤杞綍緇勫鍜屼唬璋㈢粍瀛︾浉緇撳悎鐨勬妧鏈紝鐮旂┒鎻ず浜?jiǎn)姹炴毚闇插涓崕椴庲q間綋鐨勭幆澧冩瘨鐞嗗拰鑽悊瀛︿綔鐢ㄦ満鍒躲�傜粨鏋滃彂鐜幫細(xì)錛?錛夋睘鏆撮湶寮曡搗騫奸矌浣撳唴緇嗚優(yōu)姣掓�э紝鏈轟綋閫氳繃涓婅皟澶氭硾绱燗鍜岀粍緇囪泲鐧介叾B鍩哄洜琛ㄨ揪浠ヤ績(jī)榪涜泲鐧借川闄嶈В錛涳紙2錛夋睘鏆撮湶寮曡搗騫奸矌蹇?jī)琛�綆＄郴緇熸瘨鎬э紝鐩稿叧鏍囧織鐗╁彂鐢熸樉钁楀彉鍖栵紝鍖呮嫭蹇?jī)鎴块挔灏胯偨锛圓NP錛夈�佽綆＄揣寮犵礌杞崲閰訛紙ACE錛夊拰紲炵粡鑲紽MRFamide鍙椾綋錛涳紙3錛夋睘鏆撮湶瑙﹀彂鑴傝川浠ｈ阿绱婁貢錛屽鑷寸値鎬ц剛璐ㄦ憾琛�紓瘋剛閰拌儐紕憋紙lysoPC錛夈�佺櫧涓夌儻D4鍜屽墠鍒楄吅绱燛2寮傚父澧炲姞錛涳紙4錛夌粏鑳?yōu)鑹茬礌P450s閫氳礬鐨勯噸瑕佸熀鍥犺嬋�媧伙紝浜х敓鎶楃値鐗╄川閲嶅緩浣撳唴紼蟲�侊紝涓鴻瘎浼版睘姣掓�ф彁渚涗簡(jiǎn)鏁忔劅鐨勬寚鏍囷紱錛?錛夋睘鏆撮湶寮曡搗綺炬皚閰哥敓鎴愬彈闃伙紝鍙兘閫氳繃鐮村潖mTOR淇″彿閫氳礬鑰屽獎(jiǎng)鍝嶅辜椴庣敓闀垮彂鑲詫紱錛?錛変唬璋㈢墿S-鑵鴻嫹鐢茬～姘ㄩ吀鍜岀簿鑳哄鍔狅紝鎻愮ず鑳?yōu)鍐呯敳鍩轰緵浣撳まp 錛屽彲鑳戒笌姹炵殑鐢插熀鍖栨湁鍏熾�?/p>
姝ゅ墠錛屽崡嫻鋒墍鍥㈤槦鍙戣〃浜庛�婄敓鎬佹瘨鐞嗗鎶ャ�嬬殑鈥淗g2+ 瀵逛腑鍥介矌騫間綋鎬ユ�ф瘨鎬у強(qiáng)MT 鐨勮瀵兼晥搴斺�濓紙2020錛?5( 6) : 300-307錛夎鏂囧凡琛ㄦ槑錛孒g2+瀵歸矌騫間綋鐨勬瘨鎬х被鍨嬩負(fù)鎬ユ�р叀錛屽叾24h銆?8h銆?2h鍜?6h鐨凩C50鍒嗗埆涓?5.013銆?.084銆?.008鍜?.683 mg鈥-1錛屽畨鍏ㄨ川閲忔祿搴︿負(fù)0.473 mg鈥-1銆傚伐涓氭椂浠ｇ幆澧冧腑姹炴薄鏌撶殑澧炲姞鍙兘浼?xì)杩涗竴姝ュ嵄鍙?qiáng)璇ョ墿绉嶃�傜粨鍚堟嬈＄爺絀剁粨鏋滐紝榪涗竴姝ユ繁鍏ユ彮紺烘睘褰卞搷椴庡辜浣撲唬璋㈢ǔ鎬佺殑姣掔悊鍜岃嵂鐞嗗浣滅敤鏈哄埗錛屾湭鏉ュ湪涓崕椴庣殑鍏蜂綋淇濇姢鎺柦鏂歸潰涓嶅簲蹇借嫻鋒磱鐜姹℃煋銆?/p>
璁烘枃閾炬帴錛?/p>
https://www.sciencedirect.com/science/article/pii/S1382668923002879
錛堝樊寮傝〃杈懼熀鍥?/span>DEGs鍒嗗竷鍜?/span>KEGG閫氳礬娉ㄩ噴錛?/span>
錛堜笌鑴傝川浠ｈ阿鐩稿叧鐨勫樊寮備唬璋駭鐗╃儹鍥撅級(jí)
寰俊鎵竴鎵?br>鍒嗕韓鍒版湅鍙嬪湀
榪戞棩錛屼腑鍥芥按浜х瀛︾爺絀墮櫌鍗楁搗姘翠駭鐮旂┒鎵�涓崕椴庝繚鎶ょ爺絀跺洟闃熷湪鐜閲嶉噾灞炴睘姹℃煋鐗╁涓崕椴庡辜浣撶殑姣掓�ф満鍒剁爺絀跺彇寰楁柊榪涘睍錛屼負(fù)寮�灞曟繏鍗辯墿縐嶄腑鍗庨矌鐨勬搗媧嬬幆澧冮闄╄瘎浼版彁渚涗簡(jiǎn)縐戝渚濇嵁銆傜浉鍏崇爺絀舵垚鏋滀互鈥?span style="font-family: "times new roman";">Integrated transcriptomics and metabolomics reveal the toxic mechanisms of mercury exposure to an endangered species Tachypleus tridentatus鈥濅負(fù)棰樺彂琛ㄤ簬Environmental Toxicology and Pharmacology鏈熷垔錛圛F 4.3錛変笂錛堣阿鏈ㄥ▏鍜岄矋铏炲洯涓哄叡鍚岀涓�浣滆�咃紝棰夋檽鍕囧崥澹負(fù)閫氳浣滆�咃級(jí)銆?/p>
姹炴槸涓�縐嶄互澶氱褰㈠紡銆佸箍娉涜�屾寔涔呭湴姹℃煋姘翠綋鐨勯噸閲戝睘錛屽叿鏈夐珮姣掓�с�侀潪鐢熺墿闄嶈В鎬у拰鐢熺墿瀵岄泦鎬э紝琚仈鍚堝浗鐜瑙勫垝緗插垪涓哄鍏ㄧ悆鑼冨洿浜х敓褰卞搷鐨勫寲瀛︾墿璐紝宸叉垚涓哄叏鐞冨箍娉涘叧娉ㄧ殑鐜姹℃煋鐗╀箣涓�銆?/p>
鍗楁搗鎵�鍥㈤槦搴旂敤杞綍緇勫鍜屼唬璋㈢粍瀛︾浉緇撳悎鐨勬妧鏈紝鐮旂┒鎻ず浜?jiǎn)姹炴毚闇插涓崕椴庲q間綋鐨勭幆澧冩瘨鐞嗗拰鑽悊瀛︿綔鐢ㄦ満鍒躲�傜粨鏋滃彂鐜幫細(xì)錛?錛夋睘鏆撮湶寮曡搗騫奸矌浣撳唴緇嗚優(yōu)姣掓�э紝鏈轟綋閫氳繃涓婅皟澶氭硾绱燗鍜岀粍緇囪泲鐧介叾B鍩哄洜琛ㄨ揪浠ヤ績(jī)榪涜泲鐧借川闄嶈В錛涳紙2錛夋睘鏆撮湶寮曡搗騫奸矌蹇?jī)琛�綆＄郴緇熸瘨鎬э紝鐩稿叧鏍囧織鐗╁彂鐢熸樉钁楀彉鍖栵紝鍖呮嫭蹇?jī)鎴块挔灏胯偨锛圓NP錛夈�佽綆＄揣寮犵礌杞崲閰訛紙ACE錛夊拰紲炵粡鑲紽MRFamide鍙椾綋錛涳紙3錛夋睘鏆撮湶瑙﹀彂鑴傝川浠ｈ阿绱婁貢錛屽鑷寸値鎬ц剛璐ㄦ憾琛�紓瘋剛閰拌儐紕憋紙lysoPC錛夈�佺櫧涓夌儻D4鍜屽墠鍒楄吅绱燛2寮傚父澧炲姞錛涳紙4錛夌粏鑳?yōu)鑹茬礌P450s閫氳礬鐨勯噸瑕佸熀鍥犺嬋�媧伙紝浜х敓鎶楃値鐗╄川閲嶅緩浣撳唴紼蟲�侊紝涓鴻瘎浼版睘姣掓�ф彁渚涗簡(jiǎn)鏁忔劅鐨勬寚鏍囷紱錛?錛夋睘鏆撮湶寮曡搗綺炬皚閰哥敓鎴愬彈闃伙紝鍙兘閫氳繃鐮村潖mTOR淇″彿閫氳礬鑰屽獎(jiǎng)鍝嶅辜椴庣敓闀垮彂鑲詫紱錛?錛変唬璋㈢墿S-鑵鴻嫹鐢茬～姘ㄩ吀鍜岀簿鑳哄鍔狅紝鎻愮ず鑳?yōu)鍐呯敳鍩轰緵浣撳まp 錛屽彲鑳戒笌姹炵殑鐢插熀鍖栨湁鍏熾�?/p>
姝ゅ墠錛屽崡嫻鋒墍鍥㈤槦鍙戣〃浜庛�婄敓鎬佹瘨鐞嗗鎶ャ�嬬殑鈥淗g2+ 瀵逛腑鍥介矌騫間綋鎬ユ�ф瘨鎬у強(qiáng)MT 鐨勮瀵兼晥搴斺�濓紙2020錛?5( 6) : 300-307錛夎鏂囧凡琛ㄦ槑錛孒g2+瀵歸矌騫間綋鐨勬瘨鎬х被鍨嬩負(fù)鎬ユ�р叀錛屽叾24h銆?8h銆?2h鍜?6h鐨凩C50鍒嗗埆涓?5.013銆?.084銆?.008鍜?.683 mg鈥-1錛屽畨鍏ㄨ川閲忔祿搴︿負(fù)0.473 mg鈥-1銆傚伐涓氭椂浠ｇ幆澧冧腑姹炴薄鏌撶殑澧炲姞鍙兘浼?xì)杩涗竴姝ュ嵄鍙?qiáng)璇ョ墿绉嶃�傜粨鍚堟嬈＄爺絀剁粨鏋滐紝榪涗竴姝ユ繁鍏ユ彮紺烘睘褰卞搷椴庡辜浣撲唬璋㈢ǔ鎬佺殑姣掔悊鍜岃嵂鐞嗗浣滅敤鏈哄埗錛屾湭鏉ュ湪涓崕椴庣殑鍏蜂綋淇濇姢鎺柦鏂歸潰涓嶅簲蹇借嫻鋒磱鐜姹℃煋銆?/p>
璁烘枃閾炬帴錛?/p>
https://www.sciencedirect.com/science/article/pii/S1382668923002879
錛堝樊寮傝〃杈懼熀鍥?/span>DEGs鍒嗗竷鍜?/span>KEGG閫氳礬娉ㄩ噴錛?/span>
錛堜笌鑴傝川浠ｈ阿鐩稿叧鐨勫樊寮備唬璋駭鐗╃儹鍥撅級(jí)
綺ゅ叕緗戝畨澶?4010502001742鍙?/a>